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Human muscle fiber fine structure: morphometric data on controls.

F Jerusalem, A G Engel, H A Peterson

    Neurology
    |February 1, 1975
    PubMed
    Summary
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    This study quantitatively analyzed human muscle fiber ultrastructure, revealing average mitochondrial volume at 4% and specific surface areas for sarcotubular systems. Findings provide a baseline for muscle fiber characterization.

    Area of Science:

    • Muscle physiology and cellular biology.
    • Human skeletal muscle ultrastructure.

    Background:

    • Understanding normal human muscle fiber composition is crucial for interpreting pathological changes.
    • Quantitative data on mitochondrial and sarcotubular systems are essential for cell biology.

    Purpose of the Study:

    • To quantitatively analyze the fine structure of human muscle fibers.
    • To establish baseline data for mitochondrial volume, mitochondrial size, and sarcotubular surface area.
    • To evaluate the feasibility of ultrastructural typing of human muscle fibers.

    Main Methods:

    • Quantitative analysis of muscle fiber fine structure.
    • Longitudinal and transverse sectioning of muscle fibers from 10 healthy control subjects.
    • Measurement of mitochondrial fraction, mitochondrial size, sarcotubular surface area, and lipid droplet content.

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    Main Results:

    • Average mitochondrial fraction of fiber volume is approximately 4%.
    • Mean mitochondrial size is about 0.1 µm².
    • Sarcotubular surface area per unit fiber volume is ~1.5 µm²/µm³ in transverse sections.
    • Lipid droplets are present in one-third of fibers, accounting for ~0.12% of fiber volume.

    Conclusions:

    • Established quantitative ultrastructural parameters for healthy human muscle fibers.
    • Demonstrated variations in muscle fiber composition related to age, sex, and muscle type.
    • Evaluated the potential for ultrastructural fiber typing.