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Updated: Aug 14, 2026
12:06
Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
Published on: November 25, 2017
Sialic acids: fascinating sugars in higher animals and man
1Biochemical Institute, University of Kiel, Olshausenstrasse 40, D-24098 Kiel, Germany. schauer@biochem.uni-kiel.de
Zoology (Jena, Germany)
|December 15, 2005
Summary
Sialic acids are vital acidic monosaccharides in higher animals, crucial for cell membranes and diverse biological functions. Their complex biosynthesis and roles in cell interactions, disease, and evolution are highlighted.
Area of Science:
- Biochemistry
- Cell Biology
- Glycobiology
Background:
- Sialic acids are acidic monosaccharides essential for higher animals and some microorganisms.
- They are integral components of complex carbohydrates, particularly on cell membranes.
- Their high structural diversity and complex biosynthesis underscore their biological significance.
Purpose of the Study:
- To explore the multifaceted roles of sialic acids in biological systems.
- To discuss their influence on enzyme activity, cell functions, and disease.
- To examine their evolutionary implications and impact on organismal defense.
Main Methods:
- Literature review and synthesis of existing research on sialic acids.
- Analysis of sialic acid structure, biosynthesis, and function.
- Discussion of their involvement in cellular processes and pathological conditions.
Main Results:
- Sialic acids modulate glycoconjugate turnover by influencing sialidase activity.
- They serve dual roles as protective shields and recognition sites for pathogens and receptors.
- Sialic acids are implicated in viral infections, tumor biology, and immune responses.
Conclusions:
- Sialic acids are versatile molecules that finely tune cell biological events.
- Their evolution may have enhanced organismal resilience.
- Disruptions in sialic acid metabolism are linked to various diseases.
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