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Updated: Aug 14, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Gastroesophageal reflux and obstructive sleep apnea syndrome]
E Esteller1, I Modolell, F Segarra
1Servicio de Otorrinolaringología, Hospital General de Catalunya, San Cugat del Vallès, Barcelona. esteller@abaforum.es
Introduction:
Patients with mild or moderate Sleep Apnea Syndrome (SAS) need wider therapeutic scope options according to their disease severity.
Aim:
To consider including proton pump inhibitors (PPI) to the therapeutical alternatives of these patients.
Material And Methods:
A prospective study was designed, among patients with SAS. Nocturnal polysomnography and double channel pHmetry were performed simultaneously.
Results:
From the 18 patients included in this preliminary phase, in three (16.7%) nocturnal proximal ph monitoring was positive. These 3 patients were treated with PPI during at least 3 months with a very satisfactory outcome in two of them.
Conclusions:
Treatment with PPI may be a useful therapeutical alternative in patients with mild to moderate SAS.
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