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Updated: Aug 14, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Multicomponent one-pot procedure for the synthesis of free alpha-chiral amines from aldehydes
Alexandre Côté1, André B Charette
1Département de Chimie, Université de Montréal, P.O. 6128, Station Downtown, Montréal, Québec, Canada H3C 3J7.
Abstract:
[reaction: see text] The synthesis of free alpha-chiral amines by a one-pot multicomponent procedure from commercially available starting materials is described. This enantioselective reaction involves a catalytic asymmetric addition of dialkylzinc reagents to N-diphenylphosphinoylimines with use of an air-stable precatalyst complex 1. The alpha-chiral amines are prepared with a one-pot procedure from alkyl and aryl aldehydes in good yield (41-90%) and with excellent enantioselectivity (90-97% ee).
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