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Expression of keratins 14, 10 and 16 in marginal keratoderma of the palms

Marcius Achiame Peryassu1, Gerson Cotta-Pereira, Marcia Ramos-e-Silva

  • 1Postgraduation Course and Section of Dermatology, University Hospital (HUCFF-UFRJ) and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. peryassu@globo.com

Acta Dermatovenerologica Croatica : ADC
|December 17, 2005
PubMed

Insights

Marginal keratoderma of the palms (MKP) shows altered keratin expression, with reduced keratins 14 and 10 but increased keratin 16. This suggests epidermal growth factor receptor stimulation contributes to hyperkeratosis in MKP.

Area of Science:

  • Dermatology
  • Cell Biology
  • Biochemistry

Background:

  • Marginal keratoderma of the palms (MKP), or degenerative collagenous plaques of the hands, is a rare condition.
  • It affects individuals with photoaged skin and hand trauma.

Purpose of the Study:

  • To investigate keratin 14 (K14), keratin 10 (K10), and keratin 16 (K16) expression in MKP.
  • To determine the role of growth factors and epidermal growth factor receptors in MKP hyperkeratosis.

Main Methods:

  • Immunohistochemical staining using monoclonal antibodies was performed on 14 MKP patients.
  • Standard immunoperoxidase method visualized keratin expression.
  • Three normal skin samples served as controls.

Main Results:

  • MKP patients exhibited weak or absent expression of K14 (basal layer) and K10 (suprabasal layer).
  • A strong expression of K16 was observed in MKP patients.
  • Controls showed normal keratin expression patterns.

Conclusions:

  • MKP is characterized by altered keratin profiles: reduced K14/K10 and elevated K16.
  • Ultraviolet radiation and trauma likely stimulate epidermal growth factor receptors, contributing to MKP pathogenesis.

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