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Phytoextract-induced developmental deformities in malaria vector.

Preeti Sharma1, Lalit Mohan, C N Srivastava

  • 1Applied Entomology and Vector Control Laboratory, Department of Zoology, Faculty of Science, Dayalbagh Educational Institute (Deemed University), Dayalbagh, Agra 282 005, India.

Bioresource Technology
|December 17, 2005
PubMed
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Petroleum ether extract of Artemisia annua demonstrated significant larvicidal activity against the malaria vector Anopheles stephensi. This plant extract also disrupted the vector

Area of Science:

  • Medical Entomology
  • Natural Product Chemistry
  • Vector Control

Background:

  • Malaria remains a significant global health threat, primarily transmitted by Anopheles mosquitoes.
  • Effective vector control strategies are crucial to combat malaria transmission.
  • Plant-derived compounds offer potential for developing novel and eco-friendly insecticides.

Purpose of the Study:

  • To evaluate the larvicidal potential of three plant extracts against the malaria vector Anopheles stephensi.
  • To investigate the effect of the most potent extract on the metamorphosis and development of An. stephensi.

Main Methods:

  • Larvicidal bioassays were conducted using petroleum ether, carbon tetrachloride, and methanol extracts of Artemisia annua, Chenopodium album, and Sonchus oleraceus.
  • Concentration-mortality (LC50) values were determined at 24 and 48 hours.

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  • The effect on hatching, larval and pupal periods, and adult emergence was assessed for the most effective extract.
  • Main Results:

    • Petroleum ether extract of Artemisia annua exhibited the highest larvicidal activity (LC50 16.85 ppm at 24h, 11.45 ppm at 48h).
    • Other effective extracts included Cte of A. annua, Ch. album, and Pee of Ch. album.
    • Methanol extract of Ch. album and all extracts of S. oleraceous showed no significant larvicidal activity.
    • The A. annua petroleum ether extract reduced hatching, larval/pupal emergence, and growth index, while lengthening developmental periods.

    Conclusions:

    • Artemisia annua petroleum ether extract is a potent larvicide against Anopheles stephensi.
    • This extract effectively disrupts the life cycle and metamorphosis of the malaria vector.
    • Artemisia annua holds promise as a natural biocontrol agent for malaria vector management.