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Reactive oxidant species in asthma.
Judith C W Mak1, Moira M W Chan-Yeung
1Division of Respiratory Medicine, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China. judithmak@hkucc.hku.hk
Current Opinion in Pulmonary Medicine
|December 17, 2005
Summary
Oxidant-antioxidant balance in asthma shows conflicting results, with increased reactive oxygen species and altered antioxidant levels. Antioxidant compounds may aid asthma treatment, particularly during exacerbations.
Area of Science:
- Biochemistry
- Pulmonology
- Oxidative Stress Research
Background:
- Asthma involves an imbalance between oxidants and antioxidants.
- Reactive oxygen species (ROS) are elevated in asthma patients.
- Endogenous antioxidants play a crucial role in mitigating ROS damage.
Purpose of the Study:
- To review and compare recent studies on oxidant-antioxidant balance in asthma.
- To analyze changes in oxidants/antioxidants during stable asthma and acute exacerbations.
Main Methods:
- Literature review of recent studies on asthma and oxidative stress.
- Analysis of findings related to reactive oxygen species production.
- Evaluation of alterations in antioxidant levels and enzyme activities.
Main Results:
- Conflicting findings reported regarding antioxidant enzyme activity in asthma.
- Increased production of reactive oxygen species (e.g., superoxide anion, hydrogen peroxide) observed.
- Decreased plasma antioxidant capacity and variable superoxide dismutase activity noted.
Conclusions:
- Discrepancies in antioxidant enzyme activity require further investigation into their role in asthma pathogenesis.
- Antioxidant compounds show potential therapeutic benefits for asthma, especially exacerbations.