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[Association between serum markers for celiac and thyroid autoimmune diseases]
Francisco M de Melo1, Maria S M Cavalcanti, Severino B dos Santos
1Departamento de Patologia, Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, PE.
Arquivos Brasileiros De Endocrinologia E Metabologia
|December 17, 2005
Summary
Individuals with positive anti-thyroid antibodies show a higher prevalence of celiac disease markers. Anti-tissue transglutaminase (TGase) antibodies are a reliable screening tool for celiac disease in this population.
Area of Science:
- Immunology
- Gastroenterology
- Endocrinology
Context:
- Celiac disease (CD) is an autoimmune disorder linked to HLA-DQ2/DQ8 genes, triggered by gluten.
- CD frequently co-occurs with other autoimmune conditions, including autoimmune thyroid diseases.
- Tissue transglutaminase (TGase) is a key autoantigen in celiac disease.
Purpose:
- To assess the prevalence of IgA anti-endomysial and anti-human TGase antibodies in individuals with positive anti-thyroid antibodies (ATA).
- To evaluate the concordance between anti-endomysial and anti-human TGase antibody tests.
- To determine the diagnostic utility of anti-TGase antibodies for celiac disease screening in patients with ATA.
Summary:
- Anti-endomysial antibodies were detected in 2.2% and anti-human TGase antibodies in 3.1% of individuals with positive ATA.
- Prevalence in controls was significantly lower (0.5% and 1%, respectively).
- Odds ratios indicated a 4.42-fold increased risk for anti-endomysial and 3.12-fold for anti-TGase antibodies in the ATA group. High concordance (k=0.84) was found between the two antibody tests.
Impact:
- The study highlights a significant association between positive anti-thyroid antibodies and celiac disease markers.
- Determination of anti-TGase antibodies is confirmed as an effective screening method for celiac disease in individuals with autoimmune thyroid disease.
- This finding aids in early detection and management of celiac disease in at-risk populations.
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