Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

p63: oncogene or tumor suppressor?

Alea A Mills1

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. mills@cshl.org

Current Opinion in Genetics & Development
|December 20, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A chromosome region linked to neurodevelopmental disorders influences locomotor behavior through sex-specific neural circuits.

Nature communications·2026
Same author

PRMT5/WDR77 Enhances the Proliferation of Squamous Cell Carcinoma via the ΔNp63α-p21 Axis.

Cancers·2024
Same author

A chromosome region linked to neurodevelopmental disorders acts in distinct neuronal circuits in males and females to control locomotor behavior.

bioRxiv : the preprint server for biology·2024
Same author

Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma.

Carcinogenesis·2023
Same author

Chd5 Regulates the Transcription Factor Six3 to Promote Neuronal Differentiation.

Stem cells (Dayton, Ohio)·2023
Same author

BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network.

Nature·2022
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

The tumor suppressor gene p63

Area of Science:

  • Molecular biology
  • Cancer research
  • Genetics

Background:

  • The p53 gene family, including p53, p63, and p73, plays critical roles in cellular processes.
  • Initially considered an oncogene, wild-type p53 is now recognized as a crucial tumor suppressor.
  • The precise role of p63 in cancer remains a subject of ongoing investigation and debate.

Purpose of the Study:

  • To elucidate the in vivo function of p63 in cancer development.
  • To determine whether p63 acts as an oncogene or a tumor suppressor.
  • To investigate p63's role in apoptosis and its implications for tumor suppression.

Main Methods:

  • Analysis of mouse models to evaluate p63's tumor-suppressive capabilities.
  • Assessment of p63 expression levels in human cancers.

Related Experiment Videos

  • Investigation of p63's involvement in the apoptotic pathway.

    • Main Results:

    • p63's function is complex and context-dependent, with evidence suggesting both oncogenic and tumor-suppressive roles.
    • Dysregulation of p63 is observed in various human malignancies.
    • p63 influences apoptosis, a key mechanism in tumor suppression.

    Conclusions:

    • p63's dual role in cancer necessitates further research for therapeutic targeting.
    • Understanding p63's precise function is crucial for advancing cancer treatment strategies.
    • p63 is implicated in the complex landscape of cancer biology, potentially acting as a tumor suppressor through apoptosis.