Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Defective gap junctional intercellular communication in the carcinogenic process.

Marc Mesnil1, Sophie Crespin, José-Luis Avanzo

  • 1Equipe Interactions et Communications Cellulaires, Institut de Physiologie et Biologie Cellulaires, CNRS-UMR 6187, Université de Poitiers, 40 avenue du Recteur Pineau, 86022 Poitiers cedex, France. marc.mesnil@univ-poitiers.fr

Biochimica Et Biophysica Acta
|December 20, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Illuminating the pleiotropic effects of bixin-loaded nanoemulsion on glioblastoma cell behavior through an integrated approach.

Molecular biology reports·2026
Same author

Lose to start, reconnect to conquer - Gap junction communication a keystone in the hallmarks of cancer.

Cancer letters·2026
Same author

Connexin-Pannexin duality in glioblastoma.

Cell and tissue research·2026
Same author

Quantification of intracellular mechanical fields in invasive cancer cells using digital volume correlation, confocal microscopy, and finite element method.

Journal of the mechanical behavior of biomedical materials·2025
Same author

Editorial: Pannexin and connexin signaling in cell death and tissue health and disease.

Frontiers in cell and developmental biology·2023
Same author

Is the Exposome Involved in Brain Disorders through the Serotoninergic System?

Biomedicines·2021

Loss of functional gap junctions, crucial for cell communication, is common in cancer. This review explores how altered gap junction proteins (connexins) and communication impact cancer progression, invasion, and metastasis.

Area of Science:

  • Cell Biology
  • Cancer Research
  • Molecular Biology

Background:

  • Gap junctions facilitate intercellular communication by allowing passage of small molecules between cells.
  • A significant decrease or absence of functional gap junctions has been observed in various cancer types.
  • This observation led to the hypothesis linking impaired gap junction communication to carcinogenesis.

Purpose of the Study:

  • To review existing data on the association between altered gap junction communication and cancer progression.
  • To analyze specific disturbances in connexin-mediated communication in cancer, including protein localization and gene mutations.
  • To examine the role of gap junction communication in cancer invasion and metastasis.

Main Methods:

  • Literature review of studies investigating gap junctions and connexins in cancer.

Related Experiment Videos

  • Analysis of data linking connexin expression and function to cancer stages.
  • Examination of specific mechanisms of gap junction dysfunction in cancer models.

    • Main Results:

    • Altered gap junctional intercellular communication capacity and connexin expression are frequently observed in cancer cells.
    • Cytoplasmic localization of connexins, lack of heterologous communication, and connexin gene mutations are implicated in cancer development.
    • Disrupted gap junction communication is associated with cancer invasion and metastasis.

    Conclusions:

    • Impaired gap junction communication and altered connexin expression are significant factors in cancer progression.
    • Understanding these alterations provides insights into carcinogenesis, invasion, and metastasis.
    • Further research into connexin-mediated communication may reveal therapeutic targets for cancer treatment.