Jove
Visualize
Contact Us

Related Concept Videos

Human Genetics01:28

Human Genetics

810
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
810
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

1.2K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.2K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

181
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
181
Depression: Overview01:18

Depression: Overview

429
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
429
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

124.6K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
124.6K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

182
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
182

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain Disorders and Chemical Pollutants: A Gap Junction Link?

Biomolecules·2021
Same author

Involvement of the Gap Junction Protein, Connexin43, in the Formation and Function of Invadopodia in the Human U251 Glioblastoma Cell Line.

Cells·2020
Same author

Direct Intercellular Communications and Cancer: A Snapshot of the Biological Roles of Connexins in Prostate Cancer.

Cancers·2019
Same journal

Precision Proteomic Profiling of Systemic Lupus Erythematosus-Correlating Disease Activity and Complement Levels with Clinical Phenotypes.

Biomedicines·2026
Same journal

The Role of Salivary Microbiota in Pancreatic Cancer: From Screening to Tumor Progression and Treatment Response.

Biomedicines·2026
Same journal

Diagnostic Utility of Surface Electromyography for Identifying Muscles Affected by Myofascial Trigger Points: A Scoping Review.

Biomedicines·2026
Same journal

Performance Assessment of a Locally Semi-Automated NGS-Based Workflow for Homologous Recombination Deficiency Testing in High-Grade Serous Ovarian Carcinoma.

Biomedicines·2026
Same journal

Coupling and Uncoupling Pleiotropy Between Hypertension and Type 2 Diabetes Contribute to Exploring Potential Heterogeneity in Cardiovascular Risk in East Asian Population.

Biomedicines·2026
Same journal

Maternal Response to Therapeutic Plasma Exchange in Early Gestation: A Case Series of Thrombotic Microangiopathies and Neurological Disorders.

Biomedicines·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Oct 16, 2025

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
07:56

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

3.5K

Is the Exposome Involved in Brain Disorders through the Serotoninergic System?

Denis Sarrouilhe1, Norah Defamie2, Marc Mesnil2

  • 1Laboratoire de Physiologie Humaine, Faculté de Médecine et Pharmacie, 6 Rue de la Milétrie, Bât D1, TSA 51115, CEDEX 09, 86073 Poitiers, France.

Biomedicines
|October 23, 2021
PubMed
Summary
This summary is machine-generated.

Environmental exposures impact the serotonin system, a key neurotransmitter. This can lead to neurodevelopmental, neurodegenerative, and neurobehavioral disorders, including glioblastoma.

Keywords:
brainglioblastomaneurobehavioral disordersneurodegenerative disordersneurodevelopmental disorderspesticidespollutantsserotonin

More Related Videos

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
08:49

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

9.0K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

3.8K

Related Experiment Videos

Last Updated: Oct 16, 2025

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
07:56

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

3.5K
Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
08:49

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

9.0K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

3.8K

Area of Science:

  • Neuroscience
  • Toxicology
  • Cell Biology

Background:

  • Serotonin (5-hydroxytryptamine, 5-HT) is a crucial biogenic monoamine with diverse roles as a neurotransmitter, local mediator, and vasoactive agent.
  • Dysregulation of the serotoninergic system is implicated in numerous central nervous system (CNS) and psychiatric disorders, contributing to neuropathies.
  • Serotonin also functions as a mitogenic factor for various normal and tumor cells, including glioma cells in vitro.

Purpose of the Study:

  • To review the impact of environmental exposures (the exposome) on the serotoninergic system.
  • To explore the potential links between serotoninergic system disruption and brain pathologies, including neurodevelopmental, neurodegenerative, and neurobehavioral disorders, as well as glioblastoma.

Main Methods:

  • Literature review of existing data on the exposome's effects on the serotoninergic system.
  • Analysis of studies investigating the role of serotonin in cell proliferation and CNS disorders.
  • Synthesis of evidence connecting environmental factors, serotonin signaling, and brain pathology development.

Main Results:

  • The developing CNS is highly vulnerable to neurotoxic substances, with perinatal exposure potentially leading to later-life diseases (developmental origin of health and disease hypothesis).
  • Certain environmental agents target the serotoninergic system, suggesting a potential role in a "silent pandemic" of neurodevelopmental toxicity.
  • Serotonin's mitogenic properties extend to tumor cells, highlighting its relevance in glioblastoma development.

Conclusions:

  • Environmental exposures significantly influence the serotoninergic system.
  • Disruption of serotonin signaling by the exposome is a plausible contributing factor to a range of brain pathologies.
  • Further research is warranted to understand and mitigate the neurodevelopmental and neurobehavioral consequences of environmental insults on the serotonin system.