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Related Experiment Videos

Chondrosarcoma: MR imaging with pathologic correlation.

D G Varma1, A G Ayala, C H Carrasco

  • 1Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

Radiographics : a Review Publication of the Radiological Society of North America, Inc
|July 1, 1992
PubMed
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Magnetic resonance imaging (MRI) effectively shows the full extent of chondrosarcomas, including intraosseous and soft-tissue involvement. However, MRI signal intensity alone cannot reliably determine the tumor

Area of Science:

  • Orthopedic Oncology
  • Radiology
  • Pathology

Background:

  • Chondrosarcoma is a malignant cartilage tumor requiring accurate staging for treatment.
  • Differentiating chondrosarcoma subtypes and grades is crucial for prognosis and management.
  • Conventional radiography and computed tomography (CT) have limitations in fully assessing tumor extent.

Purpose of the Study:

  • To evaluate the utility of magnetic resonance (MR) imaging in characterizing chondrosarcomas.
  • To correlate MR imaging findings with histopathologic features and surgical confirmation.
  • To assess the accuracy of MR imaging in depicting the intraosseous and soft-tissue extent of chondrosarcomas.

Main Methods:

  • Retrospective review of 21 surgically confirmed chondrosarcoma cases.

Related Experiment Videos

  • Correlation of MR images with plain radiographs and CT scans.
  • Visual analysis of MR signal intensity (T1-weighted and T2-weighted images) and tumor morphology.
  • Comparison of imaging findings with pathologic and surgical data.

    • Main Results:

    • Chondrosarcomas appeared lobulated with intermediate T1-weighted and high T2-weighted signal intensity across all lesions.
    • Tumor size did not correlate with the grade of chondrosarcoma.
    • Mesenchymal and dedifferentiated chondrosarcomas mimicked conventional chondrosarcoma on MR imaging.
    • Extraskeletal chondrosarcomas presented as lobulated soft-tissue masses.
    • MR imaging accurately depicted the intraosseous and soft-tissue extent of tumors, consistent with surgical and pathologic findings.

    Conclusions:

    • Visual analysis of MR signal intensity is generally insufficient to determine chondrosarcoma histologic type or grade.
    • MR imaging is highly effective for precise delineation of the full extent of chondrosarcomas.
    • MR imaging is a valuable tool for surgical planning and staging of chondrosarcomas.