Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Airway complications from topical mitomycin C.

Elizabeth McCurdy Hueman1, C Blake Simpson

  • 1University of Texas Health Science Center San Antonio, TX 78229-3900, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|December 20, 2005
PubMed
Summary

Topical mitomycin C (MMC) use in airway stenosis treatment can cause complications. This study found a 4.7% incidence of fibrinous debris accumulation, leading to airway obstruction and intervention, highlighting the need for caution.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Office-Based Procedures for Chronic Cough.

Otolaryngologic clinics of North America·2026
Same author

Diagnosis and Treatment of Refractory Chronic Cough: An American Broncho-Esophagological Association Expert Consensus Statement.

The Laryngoscope·2026
Same author

Autoimmune Disorders Affecting the Larynx: Review of Laryngoscopic Findings and Approach to Multidisciplinary Management.

The Annals of otology, rhinology, and laryngology·2026
Same author

Nebulized Lidocaine Through a Channeled Endoscope for Office Laryngology Procedures.

The Laryngoscope·2025
Same author

Factors Directing Treatment Decision-Making in the Management of Glottic Insufficiency.

The Laryngoscope·2025
Same author

Indications and Short-Term Outcomes for In-Office Therapeutic Superior Laryngeal Nerve Block.

The Annals of otology, rhinology, and laryngology·2023

Area of Science:

  • Otolaryngology
  • Medical Research
  • Surgical Adjuncts

Background:

  • Topical mitomycin C (MMC) is used to reduce airway scarring.
  • Studies show efficacy and safety at concentrations of 0.4-10 mg/mL.
  • Ophthalmology literature reports serious complications from topical MMC.

Purpose of the Study:

  • To report complications of topical MMC in glottic and subglottic stenosis treatment.
  • To identify risk factors associated with these complications.

Main Methods:

  • Retrospective chart review of patients treated for laryngotracheal stenosis.
  • Used endoscopic CO(2) laser incisions/dilation with adjuvant topical MMC.
  • Analyzed patient demographics, stenosis characteristics, comorbidities, procedure details, and MMC concentration.

Related Experiment Videos

Main Results:

  • 85 cases in 44 patients using topical MMC were reviewed.
  • 4.7% incidence (4/85 cases) of complications attributed to local MMC toxicity.
  • Complications included fibrinous debris, partial airway obstruction, and emergent intervention.

Conclusions:

  • Caution is advised when using topical mitomycin C for airway stenosis.
  • Potential for local toxicity and associated complications exists.