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Translational molecular imaging for cancer
1The Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21287-2182, USA. mpomper@jhmi.edu
Summary
Molecular imaging advances radiology research by adapting conventional methods for in vivo cellular and molecular studies. This technology offers new avenues for early cancer detection and personalized therapy, moving from lab to clinic.
Area of Science:
- Radiology
- Molecular Imaging
- Oncology
Background:
- Conventional anatomic imaging (CT, MR) is standard in diagnostics.
- Radiology research increasingly focuses on molecular imaging for in vivo cellular and molecular studies.
- Molecular imaging, rooted in nuclear medicine, is expanding to other modalities for noninvasive physiology assessment.
Purpose of the Study:
- To review promising molecular imaging areas for oncology.
- To emphasize techniques with immediate clinical translation potential.
- To highlight the shift from laboratory research to clinical application in molecular imaging.
Main Methods:
- Review of targeted contrast agents for MR imaging.
- Assessment of high-resolution techniques in various imaging modalities.
- Focus on noninvasive assessment of physiology and molecular events.
Main Results:
- Molecular imaging offers potential for early cancer detection.
- It supports personalized cancer therapy strategies.
- Several molecular imaging technologies are nearing clinical readiness.
Conclusions:
- Molecular imaging represents a significant advancement in oncology.
- Clinical translation of advanced molecular imaging techniques is imminent.
- This field promises to revolutionize cancer diagnosis and treatment.