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Postprandial peptide YY release is mediated by cholecystokinin
D W McFadden1, M Rudnicki, B Kuvshinoff
1Department of Surgery, University of Cincinnati College of Medicine, Ohio 45267-0558.
Surgery, Gynecology & Obstetrics
|August 1, 1992
Summary
Cholecystokinin (CCK) stimulates the release of Peptide YY (PYY) and Pancreatic Polypeptide (PP) after meals. Blocking CCK receptors prevents this release, suggesting CCK mediates PYY and PP release.
Area of Science:
- Gastroenterology
- Endocrinology
- Neuroscience
Background:
- Peptide YY (PYY) is a gastrointestinal peptide involved in regulating digestive functions.
- The specific triggers for PYY release are not fully understood, but foregut signals are suspected.
- Cholecystokinin (CCK) is a key hormone stimulating pancreatic and gastric secretions.
Purpose of the Study:
- To investigate the role of Cholecystokinin (CCK) in triggering postprandial Peptide YY (PYY) release.
- To explore the potential involvement of CCK in the release of Pancreatic Polypeptide (PP).
Main Methods:
- Conscious dogs were administered a fat meal or a continuous intravenous infusion of CCK-8.
- Dogs were pretreated with L-364,718, a specific CCK receptor antagonist, on separate occasions.
- Peripheral blood samples were collected to measure PYY, PP, and neuropeptide Y levels via radioimmunoassay.
Main Results:
- Both a fat meal and exogenous CCK administration significantly increased circulating levels of PYY and PP.
- Pretreatment with the CCK receptor antagonist L-364,718 completely abolished the stimulated release of PYY and PP.
- These findings indicate that CCK plays a crucial role in mediating the postprandial release of PYY and PP.
Conclusions:
- Cholecystokinin (CCK) is a physiological mediator of postprandial Peptide YY (PYY) and Pancreatic Polypeptide (PP) release.
- The results suggest an inhibitory feedback mechanism between hindgut PYY and foregut CCK.
- This study elucidates a key hormonal interaction in gastrointestinal regulation.