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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Epithelioid sarcoma associated with lung adenocarcinoma
Shinji Kagami1, Hidehisa Saeki, Takeo Idezuki
1Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
The Journal of Dermatology
|December 20, 2005
Summary
Epithelioid sarcoma, a rare soft tissue cancer, was diagnosed in a patient with a history of malignancy and familial cancer. Despite treatment, metastasis occurred, highlighting the challenges in managing this infiltrating tumor.
Area of Science:
- Oncology
- Pathology
- Dermatology
Background:
- Epithelioid sarcoma is a rare soft tissue malignancy often misdiagnosed.
- Its infiltrating growth pattern frequently leads to recurrence and metastasis.
- A case report is presented to illustrate diagnostic and management challenges.
Observation:
- A 49-year-old man presented with a forearm ulcer after trauma.
- He had a personal history of seminoma and a family history of carcinomas.
- Histopathology confirmed epithelioid sarcoma; lung nodules revealed adenocarcinoma.
Findings:
- Immunohistochemistry showed epithelioid sarcoma markers (cytokeratins, EMA, CD34, vimentin).
- The patient received conservative treatment including radiation, thermotherapy, and chemotherapy.
- Despite initial response, epithelioid sarcoma metastasis was detected in axillary lymph nodes four years later.
Implications:
- This case underscores the importance of considering epithelioid sarcoma in unexplained lesions, especially with risk factors.
- The co-occurrence of epithelioid sarcoma and adenocarcinoma warrants further investigation into potential shared oncogenic pathways.
- Management strategies for epithelioid sarcoma require careful consideration of tumor biology, patient factors, and potential for metastasis.
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