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Morbilliviruses and human disease.

Bertus K Rima1, W Paul Duprex

  • 1School of Biomedical Sciences and Centre for Cancer Research and Cell Biology, The Queen's University of Belfast, UK. b.rima@qub.ac.uk

The Journal of Pathology
|December 20, 2005
PubMed
Summary

Morbilliviruses, including measles virus (MV), can cause a spectrum of human diseases. This review categorizes diseases linked to morbillivirus infections, distinguishing confirmed, potential, and unsubstantiated associations.

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Area of Science:

  • Virology
  • Pathogenesis
  • Epidemiology

Background:

  • Morbilliviruses, part of the Paramyxoviridae family, include notable viruses like measles virus (MV).
  • Historically, viral identification relied on Koch's postulates; modern molecular assays enable detection in unestablished viral etiologies.
  • Modified Koch's postulates (Bradford Hill criteria) are used to link viruses to diseases when traditional methods are insufficient.

Purpose of the Study:

  • To review and categorize human diseases associated with morbillivirus infections.
  • To differentiate between diseases definitively caused by morbilliviruses, those potentially exacerbated by them, and those with weak or no evidence of association.
  • To clarify published data and separate scientifically supported links from anecdotal associations.

Main Methods:

  • Literature review and data synthesis.
  • Categorization of human diseases based on the strength of evidence linking them to morbillivirus infection.
  • Critical evaluation of scientific data to distinguish confirmed, potential, and unsubstantiated associations.

Main Results:

  • Human diseases linked to morbilliviruses fall into three categories: definitely caused, potentially exacerbated, and unsubstantiated.
  • The review aims to provide clarity on the scientific evidence supporting these associations.
  • Distinguishing between confirmed and anecdotal links is crucial for accurate understanding and research direction.

Conclusions:

  • Morbillivirus infections are associated with a range of human health conditions.
  • A clear classification system helps in understanding the true impact of morbilliviruses on human health.
  • Further research is needed to solidify or refute suspected morbillivirus-disease links.

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