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Related Experiment Videos

[Increased nuchal translucency with normal karyotype].

Kypros H Nicolaides1, Piotr Wegrzyn

  • 1Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.

Ginekologia Polska
|December 21, 2005
PubMed
Summary

Increased nuchal translucency (NT) in fetuses can indicate chromosomal issues or fetal death. This review helps counsel parents by estimating survival and healthy delivery chances for chromosomally normal fetuses with increased NT.

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Area of Science:

  • Prenatal diagnosis
  • Fetal medicine
  • Genetics

Background:

  • Increased fetal nuchal translucency (NT) is linked to trisomy 21, other chromosomal abnormalities, fetal death, and malformations.
  • NT measurement is a key early marker in fetal development and screening.

Purpose of the Study:

  • To review outcomes for chromosomally normal fetuses with increased NT.
  • To provide data for counseling parents and planning follow-up investigations.

Main Methods:

  • Review of outcomes based on NT measurements in chromosomally normal fetuses.
  • Analysis of NT thickness in relation to fetal crown-rump length (CRL).

Main Results:

  • NT thickness increases with CRL; median NT at CRL 45mm is 1.2mm, at CRL 84mm is 1.9mm.

Related Experiment Videos

  • The 95th centile for NT is 2.1mm at CRL 45mm and 2.7mm at CRL 84mm.
  • Increased NT (above 95th centile) can resolve after 14 weeks or evolve into nuchal edema/cystic hygromas.

    • Conclusions:

    • Data allows estimation of intrauterine survival and healthy delivery chances for fetuses with increased NT.
    • Provides valuable information for parental counseling and management of pregnancies with increased NT.