Related Experiment Video

Updated: Aug 14, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

[Choosing the right medication for the right patient]

Eric Durand1, Zena Kadri, Nicolas Danchin

  • 1Service de cardiologie médicale, Hôpital européen Georges Pompidou, 75908 Paris.

La Revue Du Praticien
|December 21, 2005
PubMed

Insights

Effective medications like antiplatelet agents, beta-blockers, statins, and ACE inhibitors are crucial for preventing and treating atherosclerosis. Lifestyle changes are also essential for managing cardiovascular health.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Context:

  • Atherosclerosis is a significant contributor to cardiovascular morbidity and mortality.
  • Medical therapy has evolved significantly over the past 15 years for managing atherosclerosis.

Purpose:

  • To outline the primary objectives of medical therapy in atherosclerosis: halting disease progression, managing risk factors, and alleviating symptoms.
  • To identify key medication classes proven to reduce mortality and adverse cardiovascular events.

Summary:

  • Four primary medication classes—antiplatelet agents, beta-blockers, statins, and Angiotensin-Converting Enzyme (ACE) inhibitors—demonstrate major clinical benefits in reducing mortality and severe adverse cardiovascular events.
  • These medications are recommended as first-line therapy for atherosclerosis management.
  • Adjunctive lifestyle modifications, including a Mediterranean diet, regular physical exercise, and smoking cessation, are vital components of comprehensive atherosclerosis treatment.

Impact:

  • Establishes a clear therapeutic strategy for the prevention and treatment of atherosclerosis.
  • Highlights the importance of a multi-faceted approach combining pharmacotherapy and lifestyle interventions for optimal patient outcomes.
  • Provides evidence-based recommendations for clinicians managing patients with atherosclerotic disease.

Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
Dosage Interval and Administration Route: Determination Methods01:19

Dosage Interval and Administration Route: Determination Methods

A medication’s effectiveness largely depends on its appropriate dosage and the route of administration. Dosage ensures that a sufficient drug concentration is maintained in the bloodstream to elicit the desired therapeutic effect without causing toxicity. The route of administration affects the drug's bioavailability, rate of absorption, and onset of action, which are crucial for achieving optimal therapeutic outcomes. Drug dosage calculations are critical to tailoring therapy to individual...
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady state,...
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...