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[SARS coronavirus].

Fumihiro Taguchi1

  • 1Department of Virolgy III, National Institute of Infectious Diseases.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 21, 2005
PubMed
Summary

Severe Acute Respiratory Syndrome (SARS) is a novel infectious pneumonia caused by SARS coronavirus (SCoV). This review details SCoV virology, comparing it to other coronaviruses, and speculates on its origin.

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Area of Science:

  • Virology
  • Infectious Diseases
  • Genomics

Context:

  • Emergence of SARS in China (2002) and global outbreak (2003).
  • Significant mortality (approx. 800 deaths) primarily in Asian countries.
  • Rapid isolation and sequencing of the SARS coronavirus (SCoV).

Purpose:

  • To provide a comprehensive review of SARS-CoV virology.
  • To compare SCoV with other well-studied coronaviruses.
  • To discuss viral taxonomy, virion structure, genome, proteins, replication, receptors, and pathogenesis.

Summary:

  • Identification of SARS-CoV as a novel coronavirus distinct from known human and animal coronaviruses.
  • SARS-CoV is one of the most extensively studied coronaviruses due to widespread research.
  • The review covers SCoV's biological characteristics and pathogenesis.

Impact:

  • Facilitated understanding of a new human pathogen.
  • Contributed to the rapid development of diagnostic and therapeutic strategies.
  • Provided insights into coronavirus evolution and origins.

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