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Related Experiment Videos

Are glucocorticoids in ear drops ototoxic?

O Spandow1

  • 1Department of Otorhinolaryngology, University of Umeå, Sweden.

Acta Oto-Laryngologica. Supplementum
|January 1, 1992
PubMed
Summary

Ototopical drugs, including hydrocortisone, may harm the inner ear. Animal studies show hydrocortisone applied to the round window impairs auditory brainstem response (ABR) thresholds, questioning its safety.

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Area of Science:

  • Otolaryngology
  • Pharmacology
  • Neuroscience

Background:

  • Ototopical medications (antiseptics, antibiotics, solvents) can cause ototoxicity.
  • Hydrocortisone, a common anti-inflammatory steroid, is frequently combined with these drugs.
  • The ototoxic potential of hydrocortisone on the inner ear is largely unknown.

Purpose of the Study:

  • To investigate the potential adverse effects of hydrocortisone on the inner ear.
  • To evaluate the ototoxic potential of glucocorticoids, specifically hydrocortisone.

Main Methods:

  • Animal experiments involving the application of hydrocortisone in the round window niche.
  • Assessment of auditory brainstem response (ABR) thresholds.

Main Results:

  • Hydrocortisone application in the round window niche impaired ABR thresholds.
  • The impairment was observed specifically in the high-frequency range.

Conclusions:

  • Hydrocortisone may possess ototoxic potential, particularly affecting high-frequency hearing.
  • Further discussion and investigation into the ototoxicity of glucocorticoids are warranted.

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