Related Experiment Videos

Meningiomas: report of a hospital-based registry

A B Shah1, G A Muzumdar, A R Chitale

  • 1Department of Histopathology, Bombay Hospital and Medical Research Centre, 12, New Marine Lines, Mumbai. anita_bharat@hotmail.com

Indian Journal of Pathology & Microbiology
|December 22, 2005
PubMed

Insights

Meningiomas are the second most common central nervous system tumor. This study analyzed 267 meningiomas, finding most were benign, but some benign cases had post-operative mortality, especially those at the skull base.

Area of Science:

  • Neurosurgery
  • Neuropathology
  • Epidemiology

Background:

  • Meningiomas represent a significant proportion of central nervous system (CNS) tumors.
  • This study focuses on the epidemiology and characteristics of meningiomas within a hospital setting.

Purpose of the Study:

  • To conduct an epidemiologic analysis of meningiomas.
  • To present histological subclassification and discuss treatment strategies.
  • To evaluate the biological behavior and outcomes of different meningioma subtypes.

Main Methods:

  • Hospital-based epidemiologic study of 267 meningiomas.
  • Analysis of tumor location, histological type, and patient age (6-84 years).
  • Review of treatment schedules and 5-year follow-up data.

Main Results:

  • Meningiomas comprised 21% of 1321 CNS tumors, predominantly intracranial (92.5%).
  • 98% of meningiomas were histologically benign; 1.9% were malignant.
  • 11 of 261 benign meningioma patients died post-operatively, 8 with skull base tumors.

Conclusions:

  • Meningiomas are common CNS tumors, mostly benign.
  • Skull base location in benign meningiomas is associated with increased perioperative mortality.
  • Further understanding of biological behavior and treatment is crucial.

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...