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Detection and Isolation of Campylobacter spp. from Raw Meat
Published on: February 23, 2024
Is Campylobacter involved in antibiotic associated diarrhoea?
Chetana Vaishnavi1, Sukhminderjit Kaur
1Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh. cvaishnavi@sify.com
Indian Journal of Pathology & Microbiology
|December 22, 2005
Summary
Antibiotic use may increase the risk of Campylobacter jejuni enteritis, especially in non-immune individuals. This study found C. jejuni in 10.1% of hospitalized patients receiving antibiotics, suggesting a potential link to antibiotic-associated diarrhea.
Area of Science:
- Microbiology
- Infectious Diseases
- Gastroenterology
Background:
- Campylobacter jejuni is a primary cause of bacterial diarrhea.
- Antibiotic use can disrupt gut flora and impair immune responses.
- The role of antibiotics in precipitating C. jejuni enteritis is not well-established.
Purpose of the Study:
- To investigate the prevalence of C. jejuni in hospitalized patients undergoing antibiotic therapy.
- To explore the potential association between antibiotic intake and C. jejuni enteritis.
Main Methods:
- 138 stool samples from patients tested for Clostridium difficile toxin were also cultured for C. jejuni.
- Standard microbiological tests including Gram staining, oxidase, catalase, nalidixic acid sensitivity, and hippurate hydrolysis were performed.
- Samples were cultured on blood-free campylobacter selectivity agar.
Main Results:
- Campylobacter jejuni was detected in 14 (10.1%) of the 138 fecal samples.
- The majority of C. jejuni isolates (11) were from adult patients.
- Two samples positive for C. jejuni also tested positive for Clostridium difficile toxin.
Conclusions:
- Campylobacter jejuni may play a role in antibiotic-associated diarrhea, particularly in hosts with compromised immunity.
- C. jejuni enteritis could occur independently or in conjunction with C. difficile infection following antibiotic treatment.
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