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Magnesium orotate--experimental and clinical evidence.
1Pharmacology and Toxicology of Nutrition University of Hohenheim Stuttgart, Deuschland.
Summary
Magnesium orotate dihydrate effectively treats magnesium deficiency by supporting myocardial energy metabolism. Its unique properties make it suitable for patients with heart conditions, unlike other magnesium salts.
Area of Science:
- Biochemistry
- Pharmacology
- Cardiology
Background:
- Magnesium deficiency can impair myocardial energy production, particularly during hypoxic conditions.
- Orotic acid (OA) is a pyrimidine precursor that enhances cellular energy status.
- Magnesium orotate dihydrate (MO) combines magnesium (Mg) with OA, offering a unique therapeutic approach.
Purpose of the Study:
- To evaluate MO as an oral treatment for extracellular Mg deficiency.
- To explore the role of OA in improving myocardial energy metabolism and Mg retention.
- To assess MO's efficacy in conditions like post-cardiac surgery.
Main Methods:
- Administration of MO for oral Mg supplementation.
- Assessment of myocardial energy status (ATP, glycogen synthesis) in experimental models.
- Clinical observation in coronary heart patients, including those undergoing aortocoronary bypass surgery.
Main Results:
- MO serves as an effective source of Mg for treating extracellular Mg deficiency.
- OA in MO enhances myocardial ATP and glycogen synthesis, improving energy status.
- MO demonstrated efficacy in animal models and coronary heart patients with Mg depletion.
Conclusions:
- Magnesium orotate dihydrate is indicated for treating Mg deficiency, especially in cardiovascular conditions.
- The combination of Mg and OA offers cardioprotective benefits by enhancing energy metabolism and Mg retention.
- MO's poor water solubility prevents laxative effects, making it a well-tolerated Mg supplement.