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Chronic hepatitis C virus management: 2000-2005 update.

Christine A Hughes¹, Stephen D Shafran

¹Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada. christine.hughes@ualberta.ca

The Annals of Pharmacotherapy

|December 22, 2005

Summary

Recent advances in pegylated interferon and ribavirin therapy have improved chronic hepatitis C virus (HCV) management. Optimal treatment response in HCV patients depends on genotype, viral load, and adherence.

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Area of Science:

Hepatology
Virology
Pharmacology

Background:

Chronic hepatitis C virus (HCV) infection remains a significant global health concern.
Effective management strategies are crucial for improving patient outcomes and preventing long-term complications.

Purpose of the Study:

To review recent therapeutic advances in the management of chronic hepatitis C virus (HCV) infection.
To highlight key factors influencing treatment response and patient adherence.

Main Methods:

A comprehensive MEDLINE search was conducted for articles published between 2000 and July 2005.
Keywords included "hepatitis C," "interferon," "pegylated interferon," and "therapy."
Studies focused on treatment-naive patients with chronic HCV infection were selected.

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Main Results:

The combination of pegylated interferon and ribavirin has significantly improved treatment response rates in chronic HCV infection.
Overall response rates approximating 55% have been observed with current therapies.
Treatment outcomes are influenced by viral genotype, baseline viral load, and patient adherence.

Conclusions:

Current treatment regimens have enhanced the management of chronic HCV infection.
Effective management of adverse effects is vital for maximizing patient adherence and therapeutic success.
Further research is necessary to optimize HCV treatment protocols for diverse patient populations.