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Embryonic Stem Cells

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

Cardiac repair by embryonic stem-derived cells.

M Rubart¹, L J Field

¹Wells Center for Pediatric Research and Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis IN, 46202-5225, USA.

Handbook of Experimental Pharmacology

|December 24, 2005

Summary

Embryonic stem (ES) cells can become functional heart cells. These ES-derived cardiomyocytes can be transplanted to repair damaged hearts, promoting cardiac regeneration and restoring muscle mass.

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Published on: March 30, 2022

Area of Science:

Regenerative Medicine
Cardiology
Stem Cell Biology

Background:

Cell transplantation shows promise for repairing diseased hearts.
Donor cardiomyocytes can integrate into host hearts and restore function.
Embryonic stem (ES) cells differentiate into various cell types, including cardiomyocytes.

Purpose of the Study:

To investigate the potential of ES-derived cardiomyocytes for cardiac repair.
To determine if ES-derived cardiomyocytes can be used as a viable cell source for transplantation therapies.

Main Methods:

Culturing embryonic stem (ES) cells under specific conditions to induce differentiation.
Analyzing the characteristics of differentiated cells using cellular, molecular, and physiological methods.
Evaluating the potential for engraftment and functional integration of transplanted cells.

Main Results:

Embryonic stem (ES) cells robustly differentiated into cardiomyocytes in vitro.
ES-derived cardiomyocytes exhibited characteristics of early-stage cardiac cells.
Transplanted donor cardiomyocytes demonstrated stable engraftment and functional syncytium formation with host myocardium.

Conclusions:

ES-derived cardiomyocytes represent a promising and viable cell source for cardiac transplantation.
This approach holds potential for promoting regenerative growth and restoring muscle mass in diseased hearts.