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Transgenic Organisms

Transgenic Organisms

Transgenic Organisms

Transgenic Organisms

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Updated: Jun 5, 2026

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Published on: July 27, 2022

Cardiovascular research in transgenic animals.

¹Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202-2859, USA.

Trends in Cardiovascular Medicine

|January 18, 2011

Summary

Transgenic technology enables the creation of animal models to study gene function and disease. These models, particularly for cardiovascular research, offer new ways to investigate complex physiological and pathological processes.

Area of Science:

Molecular Biology
Genetics
Animal Models

Background:

Altering gene expression or activity in vivo is crucial for studying pathophysiology.
Transgenic technology provides a powerful tool for generating such experimental systems.
Traditional methods focus on gain-of-function alterations.

Purpose of the Study:

To discuss technical and practical aspects of generating transgenic animal models.
To present recent transgenic models relevant to cardiovascular research.
To highlight the utility of these models for studying complex clinical issues.

Main Methods:

Utilizing transgenic technology for gain-of-function alterations.
Employing experimental paradigms such as promoter function assessment and gene overexpression.

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Last Updated: Jun 5, 2026

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

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In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium

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Developing targeted oncogenesis and insertional mutagenesis models.

Focusing on models relevant to the cardiovascular system.

Main Results:

Established experimental paradigms for assessing gene function and overexpression.
Generated novel transgenic models for studying specific physiological processes.
Demonstrated the application of these models in cardiovascular research.
Provided insights into the generation and utility of transgenic models.

Conclusions:

Transgenic animal models are indispensable tools for advancing pathophysiology research.
Gain-of-function transgenic approaches offer versatile strategies for experimental investigation.
Recent advancements, especially in cardiovascular research, open new avenues for studying previously intractable clinical problems.