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Updated: Aug 14, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
Does complete deficiency of muscle alpha actinin 3 alter functional capacity in elderly women? A preliminary report
A F San Juan1, F Gomez-Gallego, S Cañete
1Universidad Europea de Madrid, Madrid, Spain.
Abstract:
The sarcomeric protein alpha actinin 3 is localised to the Z line of fast fibres, which are responsible for generating forceful muscle contractions at high velocity. However, a substantial proportion of healthy humans are totally deficient in this protein as they are homozygous for a premature stop codon polymorphism (R577X) in the ACTN3 gene. The purpose of this preliminary study was to assess if the presence or absence of alpha actinin 3 influences the deleterious effects of ageing on muscle output and functional capacity.
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