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beta-Carotene and alpha-tocopherol are synergistic antioxidants
1Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111-1837.
Archives of Biochemistry and Biophysics
|August 15, 1992
Abstract:
The possibility of a cooperative interaction between fat-soluble antioxidants is examined in a membrane model. A combination of beta-carotene and alpha-tocopherol results in an inhibition of lipid peroxidation significantly greater than the sum of the individual inhibitions. Our data provide the first evidence that beta-carotene can act synergistically with alpha-tocopherol as an effective radical-trapping antioxidant in membranes.