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Intravenous irinotecan plus oral ciclosporin
N S Vasudev1, S Jagdev, D A Anthoney
1Cancer Research UK Centre, Cookridge Hospital, Leeds, UK.
Abstract:
We previously reported a phase I study of intravenous irinotecan plus oral ciclosporin, in which dose-limiting diarrhoea was not observed, supporting the hypothesis that pharmacokinetic modulation of irinotecan by ciclosporin may improve its therapeutic index. We now report results of a further 34 patients treated at the recommended dose. A low rate of diarrhoea of grade 3 or above (3%) was again seen, with useful anti-tumour activity. The regimen is to be formally evaluated as part of a future phase III trial.
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