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Effects of enalapril on heart failure in hypertensive patients with diastolic dysfunction
R A González-Fernández1, P I Altieri, L M Díaz
1Department of Medicine, San Juan City Hospital, Puerto Rico University School of Medicine, Río Piedras.
Insights
Enalapril treatment improved heart failure symptoms in hypertensive patients with diastolic dysfunction. Echocardiographic parameters normalized, indicating enalapril
Area of Science:
- Cardiology
- Pharmacology
Background:
- Diastolic dysfunction is a common cause of heart failure in hypertensive patients.
- Normal systolic function does not exclude the presence of diastolic dysfunction.
Purpose of the Study:
- To evaluate the efficacy of enalapril in treating heart failure caused by diastolic dysfunction in hypertensive patients.
Main Methods:
- Ten hypertensive patients with heart failure and diastolic dysfunction were treated with enalapril (10 mg twice daily) for 9 months.
- Echocardiography was used to assess diastolic function parameters before and after treatment.
Main Results:
- All patients showed improvement in heart failure symptoms.
- Echocardiographic parameters indicative of diastolic dysfunction were normalized post-treatment.
Conclusions:
- Enalapril monotherapy is effective in managing heart failure associated with diastolic dysfunction in hypertensive individuals.
- The study suggests enalapril as a potential therapeutic agent for this specific patient group.
Abstract:
Ten hypertensive patients with symptoms of heart failure and normal systolic function but with diastolic dysfunction were treated with 10 mg enalapril twice a day for 9 +/- 3 months to evaluate the effects of this agent alone on heart failure induced by diastolic dysfunction. After therapy, all patients improved and echocardiographic parameters of diastolic dysfunction became normalized. It is concluded that enalapril appears to be useful in the treatment of heart failure in hypertensive patients with normal systolic function and diastolic dysfunction.