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Updated: Jul 4, 2026
07:19
A 96 Well Microtiter Plate-based Method for Monitoring Formation and Antifungal Susceptibility Testing of Candida albicans Biofilms
Published on: October 21, 2010
Fungal biofilms and antimycotics
Jyotsna Chandra1, Guangyin Zhou, Mahmoud A Ghannoum
1Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106-5028, USA.
Current Drug Targets
|December 27, 2005
Summary
Device-related infections are often caused by Candida biofilms, which show high resistance to antifungals. This review covers biofilm resistance mechanisms and susceptibility patterns, highlighting echinocandins and lipid formulations of amphotericin B as exceptions.
Area of Science:
- Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Device-related infections are a significant cause of nosocomial diseases.
- Pathogen biofilms on medical devices contribute to persistent infections.
- Candida species are common culprits, forming biofilms with high antifungal resistance.
Purpose of the Study:
- To review methods for evaluating Candida biofilm resistance.
- To summarize the susceptibility patterns of Candida biofilms to antifungal agents.
- To explore the mechanisms underlying antifungal resistance in Candida biofilms.
Main Methods:
- Literature review of studies on Candida biofilm formation and antifungal resistance.
- Analysis of susceptibility data for various antifungal agents against Candida biofilms.
- Examination of research investigating the molecular mechanisms of biofilm resistance.
Main Results:
- Candida biofilms exhibit substantial resistance to most antifungal drugs.
- Echinocandins and lipid formulations of amphotericin B show efficacy against Candida biofilms.
- Understanding resistance mechanisms is crucial for effective treatment strategies.
Conclusions:
- Candida biofilms pose a significant challenge in treating device-related infections.
- Targeted antifungal agents like echinocandins and liposomal amphotericin B are vital.
- Further research into resistance mechanisms can guide the development of novel therapies.
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