Related Experiment Video
Updated: Aug 14, 2026

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation
Published on: May 9, 2012
Low-frequency electrical stimulation increases muscle strength and improves blood supply in patients with chronic
Petr Dobsák1, Marie Nováková, Jarmila Siegelová
1Department of Functional Diagnostics and Rehabilitation.
Insights
Low-frequency electrical stimulation (LFES) significantly improved muscle strength and blood flow velocity in patients with severe chronic heart failure (CHF). This non-invasive therapy may be a beneficial treatment option for individuals with advanced heart failure.
Area of Science:
- Cardiovascular Medicine
- Rehabilitation Science
- Biomedical Engineering
Background:
- Advanced chronic heart failure (CHF) significantly impairs muscle function and peripheral circulation.
- Current treatment options for severe CHF have limitations in addressing muscle-related complications.
Purpose of the Study:
- To evaluate the efficacy of low-frequency electrical stimulation (LFES) in enhancing muscle strength and blood flow in patients with advanced CHF.
- To determine if LFES can be a viable therapeutic intervention for improving physical function in severe heart failure.
Main Methods:
- A cohort of 15 patients with advanced CHF (NYHA III-IV, EF 18.7%) underwent 6 weeks of daily LFES (10 Hz) on lower limb muscles.
- Muscle strength was assessed weekly using dynamometry (maximal muscle strength and isokinetic peak torque).
- Blood flow velocity (BFV) in the femoral artery was measured using Doppler velocimetry before and after the 6-week intervention period.
Main Results:
- LFES significantly increased maximal muscle strength (Fmax) by over 50% (p<0.001) and isokinetic peak torque (PTmax) by over 40% (p<0.01).
- Femoral artery blood flow velocity (BFV) showed a significant increase of approximately 35% after 6 weeks of LFES (p<0.05).
- Resting BFV did not show significant changes, suggesting improved dynamic blood supply during activity.
Conclusions:
- Six weeks of LFES demonstrated significant improvements in muscle strength and blood supply in patients with severe CHF.
- LFES presents a promising, non-invasive therapeutic strategy that could be recommended for managing patients with advanced chronic heart failure.
- Further research is warranted to explore the long-term effects and optimal parameters for LFES in CHF populations.
Background:
This study was designed to evaluate the effects of low-frequency electrical stimulation (LFES) on muscle strength and blood flow in patients with advanced chronic heart failure (CHF).
Methods And Results:
Patients with CHF (n=15; age 56.5 +/- 5.2 years; New York Heart Association III - IV; ejection fraction 18.7 +/- 3.3%) were examined before and after 6 weeks of LFES (10 Hz) of the quadriceps and calf muscles of both legs (1 h/day, 7 days/week). Dynamometry was performed weekly to determine maximal muscle strength (F(max); N) and isokinetic peak torque (PT(max); Nm); blood flow velocity (BFV) was measured at baseline and after 6 weeks of LFES using pulsed-wave Doppler velocimetry of the right femoral artery. Six weeks of LFES significantly increased F(max) (from 224.5 +/- 96.8 N to 340.0 +/- 99.4 N; p<0.001), and also PT(max) (from 94.5 +/- 41.5 Nm to 135.3 +/- 28.8 Nm; p<0.01). BFV in the femoral artery increased after 6 weeks from 35.7 +/- 15.4 cm/s to 48.2 +/- 18.1 cm/s (p<0.05); BFV values at rest before and after 6 weeks of LFES did not differ significantly.
Conclusions:
LFES may improve muscle strength and blood supply, and could be recommended for the treatment of patients with severe CHF.
Related Concept Videos
Muscle Stimulation Frequency
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Heart Failure VI: Adjunct Therapies
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be met...
Heart Failure V: Medical Management
Heart Failure Drugs: Inotropic Agents
Heart Failure II: Pathophysiology

