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Dichlorinated pulvinic acid derivative from a Malaysian Scleroderma sp
Sonia A van der Sar1, John W Blunt, Anthony L J Cole
1Department of Chemistry and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
Journal of Natural Products
|December 28, 2005
Summary
Researchers identified a new dichlorinated pulvinic acid derivative from Scleroderma fungi. This compound demonstrated moderate antimicrobial activity against Bacillus subtilis.
Area of Science:
- Mycology
- Natural Product Chemistry
- Microbiology
Background:
- Fungi are a rich source of novel chemical compounds.
- Scleroderma species are known to produce various secondary metabolites.
Purpose of the Study:
- To isolate and characterize a new compound from Scleroderma sp.
- To evaluate the antimicrobial potential of the isolated compound.
Main Methods:
- Isolation of the compound from fungal fruiting bodies.
- Structure elucidation using spectroscopic methods (NMR, MS).
- X-ray crystallographic analysis for structural confirmation.
Main Results:
- A new dichlorinated pulvinic acid derivative, methyl-3',5'-dichloro-4,4'-di-O-methylatromentate, was successfully isolated.
- The chemical structure was unequivocally determined through spectroscopic and X-ray diffraction data.
- The isolated compound exhibited moderate antimicrobial activity against Bacillus subtilis.
Conclusions:
- Methyl-3',5'-dichloro-4,4'-di-O-methylatromentate is a novel fungal metabolite.
- The compound possesses potential as a lead for developing new antimicrobial agents.