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[Thrombolysis: Bucarest registry].

M Dorobantu1, G Tatu-Chitoiu, M Cinteza

  • 1Hôpital Clinique D'urgences Floreasca, Calea Floreasca, Roumanie. mdorobantu@cmb.ro

Archives Des Maladies Du Coeur Et Des Vaisseaux
|December 29, 2005
PubMed
Summary
This summary is machine-generated.

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This study found that thrombolysis with streptokinase in Bucharest achieved acceptable in-hospital mortality and good artery reperfusion for acute myocardial infarction (AMI) patients when primary angioplasty was limited.

Area of Science:

  • Cardiology
  • Clinical Research

Context:

  • Retrospective analysis of acute myocardial infarction (AMI) treatment in Bucharest (2000-2004).
  • Limited availability of primary angioplasty necessitated evaluation of thrombolysis standard of care.

Purpose:

  • To evaluate in-hospital morbidity and mortality for AMI patients treated with thrombolysis within 12 hours of symptom onset.
  • To assess the effectiveness and safety of streptokinase in a real-world clinical setting.

Summary:

  • 1814 AMI patients received thrombolysis, predominantly streptokinase (66.21%), with a mean symptom onset to treatment time of 211.63 minutes.
  • In-hospital mortality was 11.1%, with female gender and advanced age (>75 years) as significant predictors.
  • Effective reperfusion was observed via non-invasive methods; anticoagulant, antiplatelet, ACE inhibitor, and statin use improved survival.

Related Experiment Videos

  • Heart failure was the most common complication at 1-year follow-up.

    • Impact:

    • Thrombolysis with streptokinase remains a viable treatment option for AMI in settings with limited primary angioplasty access.
    • Demonstrates acceptable outcomes regarding mortality and reperfusion rates.
    • Highlights the importance of adjunctive therapies like anticoagulants and statins for improving survival.