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An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
[Comparison of liver abscess between diabetic patients and non-diabetic patients]
Chang Jae Lee1, Dong Sik Jung, Suk Hee Jung
1Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Dong-A University, Busan, Korea.
Background/Aims:
Klebsiella pneumoniae is emerging as the leading cause for liver abscess although the most common pathogen was Escherichia coli in the past. Patients with diabetes mellitus are more likely to have a pyogenic liver abscess with gas forming infection; a gas forming pyogenic liver abscess carries a higher morbidity and mortality than the non-gas forming group. This study was conducted to clarify the clinical presentation and prognostic factors for pyogenic liver abscess in diabetic patients compared with non-diabetic patients.
Methods:
Medical records of 140 cases of patients treated for pyogenic liver abscess from January 1995 through January 2004 were reviewed retrospectively in detail.
Results:
Among 140 cases of pyogenic liver abscess, underlying diabetes was present in 26.4% (37/140). The clinical presentation between the two groups was not significantly different. The most common organism for the pyogenic abscess was K. pneumoniae in both groups. A gas forming liver abscess was discovered in only the diabetic liver abscess group, 6 of 37 patients (16%).
Conclusions:
K. pneumoniae was the most common organism cultured in both diabetic and non-diabetic liver abscess. Gas forming liver abscess was more common in diabetic patients than non-diabetic patients. Diabetic patients had more complications than non-diabetic patients.
Insights
Diabetic patients with pyogenic liver abscesses are more prone to gas-forming infections and complications. Klebsiella pneumoniae is the leading cause in both diabetic and non-diabetic patients, highlighting the need for targeted interventions.
Area of Science:
- Hepatology
- Infectious Diseases
- Endocrinology
Background:
- Pyogenic liver abscess (PLA) is increasingly caused by Klebsiella pneumoniae, shifting from previous trends where Escherichia coli was more common.
- Patients with diabetes mellitus (DM) have a higher risk of developing gas-forming PLA, associated with increased morbidity and mortality.
Purpose of the Study:
- To compare the clinical presentation and prognostic factors of PLA in diabetic patients versus non-diabetic patients.
- To identify differences in causative organisms and complication rates between the two groups.
Main Methods:
- Retrospective review of medical records for 140 patients treated for PLA between January 1995 and January 2004.
- Analysis of clinical data, including demographics, causative pathogens, presence of gas formation, and complications.
Main Results:
- Diabetes was present in 26.4% of PLA cases.
- Klebsiella pneumoniae was the predominant pathogen in both diabetic and non-diabetic patients.
- Gas-forming PLA occurred exclusively in the diabetic group (16%), with diabetic patients experiencing more complications.
Conclusions:
- Klebsiella pneumoniae is the primary pathogen for PLA in both diabetic and non-diabetic individuals.
- Gas-forming PLA and increased complications are significantly more prevalent in diabetic patients.
- Diabetes is a critical factor influencing PLA presentation and outcomes.
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