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The SRF and MCM1 transcription factors
1Imperial Cancer Research Fund, London, UK.
Current Opinion in Genetics & Development
|April 1, 1992
Abstract:
The mammalian transcription factor SRF (serum-response factor) and the related Saccharomyces cerevisiae transcription factor MCM1 are the prototypes of a new class of dimeric DNA-binding proteins. Their function is regulated in part by the interactions of their DNA-binding domains with accessory proteins. Recent work has advanced the functional characterization of the contributions of SRF and MCM1, and their accessory proteins to transcriptional activation.