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Updated: Jul 11, 2026
09:05
MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
Expression and function of microRNAs in viruses great and small
C S Sullivan1, A Grundhoff, S Tevethia
1Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco, California 94143, USA.
Cold Spring Harbor Symposia on Quantitative Biology
|March 27, 2007
Summary
DNA viruses encode microRNAs (miRNAs) using host machinery. This review covers computational and array-based methods for discovering viral miRNAs and discusses their function in polyomaviruses and herpesviruses.
Area of Science:
- Virology
- Molecular Biology
- Genetics
Background:
- DNA viruses utilize host gene expression machinery.
- Viral genomes are small, facilitating study of gene products.
- MicroRNAs (miRNAs) are key regulators of gene expression.
Purpose of the Study:
- To review computational and array-based methods for viral miRNA discovery.
- To discuss the structure and function of viral miRNAs.
- To highlight findings in polyomaviruses and herpesviruses.
Main Methods:
- Computational approaches for miRNA identification.
- Array-based methods for viral miRNA discovery.
- Analysis of miRNA structure and function.
Main Results:
- Identification of viral miRNAs in polyomaviruses and herpesviruses.
- Characterization of miRNA biogenesis and function in viral systems.
- Insights into the role of viral miRNAs in host gene regulation.
Conclusions:
- Viral miRNAs are encoded by DNA viruses and play significant roles.
- Computational and array-based methods are effective for viral miRNA discovery.
- Further research into viral miRNA function is warranted.
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