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Updated: Aug 14, 2026

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
Published on: June 8, 2022
[Influence of human gastrointestinal tract bacterial pathogens on host cell apoptosis]
Weronika Wronowska1, Renata Godlewska, Elzbieta Katarzyna Jagusztyn-Krynicka
1Zakład Genetyki Bakterii, Instytut Mikrobiologii, Uniwersytet Warszawski, Warszawa.
Abstract:
Several pathogenic bacteria are able to trigger apoptosis in the host cell, but the mechanisms by which it occurs differ, and the resulting pathology can take different courses. Induction and/or blockage of programmed cell death upon infection is a result of complex interaction of bacterial proteins with cellular proteins involved in signal transduction and apoptosis. In this review we focus on pro/anti-apoptotic activities exhibited by two enteric pathogens Salmonella enterica, Yersinia spp. and gastric pathogen Helicobacter pylori. We present current knowledge on how interaction between mammalian and bacterial cell relates to the molecular pathways of apoptosis, and what is the role of apoptosis in pathogenesis.
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