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Pathway recognition by neuronal growth cones: genetic analysis of neural cell adhesion molecules in Drosophila
1Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Current Opinion in Neurobiology
|February 1, 1992
Abstract:
Genetic analysis has finally come of age in the study of neural cell adhesion molecules and their function during growth cone guidance in Drosophila. Recent studies have shown that fasciclin II, a neural cell adhesion molecule of the immunoglobulin superfamily, functions as a recognition molecule for the MP1 axon pathway, thus serving as the first molecular confirmation for the existence of functional labels on specific axon pathways in the developing organism.