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Related Experiment Videos

The SWISS-MODEL Repository: new features and functionalities.

Jürgen Kopp1, Torsten Schwede

  • 1Biozentrum der Universität Basel and Swiss Institute of Bioinformatics, Basel, Switzerland.

Nucleic Acids Research
|December 31, 2005
PubMed
Summary
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The SWISS-MODEL Repository provides a large, updated collection of 3D protein structure models. This valuable resource aids researchers by offering detailed annotations and quality assessments for protein structures.

Area of Science:

  • Structural biology
  • Bioinformatics
  • Computational biology

Background:

  • The SWISS-MODEL Repository is a curated database of 3D protein structure models.
  • These models are generated using the SWISS-MODEL homology-modelling pipeline.
  • The repository is regularly updated to reflect the latest sequence and structure data.

Purpose of the Study:

  • To describe the SWISS-MODEL Repository and its contents.
  • To highlight the update process and data integration.
  • To detail the information provided for each model entry.

Main Methods:

  • Homology modelling using the SWISS-MODEL pipeline.
  • Integration of new protein sequences from UniProt.
  • Regular updates incorporating new template structures.

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Main Results:

  • As of September 2005, the repository contained 675,000 models for 604,000 protein sequences.
  • Each entry includes functional annotation, template selection log, alignment, and quality assessment.
  • The repository is freely accessible online.

Conclusions:

  • The SWISS-MODEL Repository is a comprehensive and dynamic resource for 3D protein models.
  • It provides essential data for understanding protein structure and function.
  • The repository facilitates research in structural biology and related fields.