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Related Concept Videos

Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...

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Updated: Jun 17, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Human protein reference database--2006 update.

Gopa R Mishra1, M Suresh, K Kumaran

  • 1Institute of Bioinformatics, International Tech Park, Bangalore 560 066, India.

Nucleic Acids Research
|December 31, 2005
PubMed
Summary
This summary is machine-generated.

The Human Protein Reference Database (HPRD) now offers over 20,000 human protein entries, becoming the largest resource for protein-protein interactions and post-translational modifications (PTMs). It integrates genomic and proteomic data for enhanced biomedical discovery.

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Area of Science:

  • Proteomics
  • Bioinformatics
  • Genomics

Background:

  • The Human Protein Reference Database (HPRD) serves as a comprehensive repository for human protein information.
  • It includes protein features, post-translational modifications (PTMs), and protein-protein interactions.
  • The database has significantly expanded since its initial report.

Purpose of the Study:

  • To detail the growth and new features of the HPRD database.
  • To highlight HPRD's role as a leading resource for human proteome data.
  • To emphasize the integration of genomic and proteomic information for advancing biomedical research.

Main Methods:

  • Expansion of protein entries to over 20,000.
  • Inclusion of over 30,000 literature-derived protein-protein interactions.
  • Incorporation of over 8,000 post-translational modifications (PTMs).

Main Results:

  • HPRD is now the largest database for literature-derived human protein-protein interactions and PTMs.
  • New features include protein isoforms, enhanced search capabilities, and linked pathway annotations.
  • Integration of the GenProt Viewer facilitates combined genomic and proteomic data analysis.

Conclusions:

  • HPRD has become a unique, curated resource for the human proteome.
  • The database supports biomedical discoveries through integrated data analysis.
  • Continued community support is expected to further enhance HPRD's utility.