Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

WormBase: better software, richer content.

Erich M Schwarz1, Igor Antoshechkin, Carol Bastiani

  • 1Division of Biology, 156-29 California Institute of Technology, Pasadena, CA, 91125, USA. emsch@its.caltech.edu

Nucleic Acids Research
|December 31, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Using a translational data platform to create clinical-grade genome-informed risk assessments.

JAMIA open·2026
Same author

Additive value of polygenic risk and family history for coronary heart disease risk stratification in two diverse US cohorts.

American journal of human genetics·2026
Same author

A cohort study of obese patients with moderate-to-severe psoriasis using biological medicines in Catalonia, Spain.

Dermatology reports·2026
Same author

Integrating social determinants of health and genetic risk in disease risk models.

American journal of human genetics·2026
Same author

Haploidentical transplant, gene therapy, and standard care in sickle cell disease: a cost-effectiveness analysis.

Blood·2026
Same author

Increasingly Reversible Na/Cl<sub>2</sub> and Li/Cl<sub>2</sub> Batteries.

Journal of the American Chemical Society·2026

WormBase, a key resource for Caenorhabditis elegans genomics, has been enhanced with improved performance and expanded biological data. This update offers users more powerful search capabilities and richer content for biological research.

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • WormBase is the primary public database for the nematode Caenorhabditis elegans.
  • Previous versions faced performance limitations and lacked comprehensive biological data integration.

Purpose of the Study:

  • To restructure WormBase for enhanced performance and expanded biological content.
  • To improve data accessibility and user query capabilities.
  • To enrich the database with reconciled genomic and functional information.

Main Methods:

  • Accelerated loading of central data pages (e.g., Gene page).
  • Rationalized internal data structures and software for portability.
  • Enhanced Genome Browser customization for viewing and exporting genomic data.

Related Experiment Videos

  • Integrated Textpresso for literature queries and WormMart for genomic data queries.
  • Reconciled cDNA and expressed sequence tag data with gene predictions.
  • Clarified single nucleotide polymorphism and RNAi sites.
  • Summarized known gene functions.

    • Main Results:

    • Significantly improved database performance and loading speeds.
    • Enabled arbitrarily complex, user-specified queries for literature and genomic data.
    • Enriched biological content through data reconciliation and functional summaries.
    • Increased portability and customizability of WormBase tools, including the Genome Browser.

    Conclusions:

    • The restructured WormBase offers a more powerful and user-friendly platform for C. elegans research.
    • Expanded data and improved performance facilitate deeper biological insights.
    • Enhanced query capabilities empower researchers to explore complex biological questions more effectively.