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The PeptideAtlas project.

Frank Desiere1, Eric W Deutsch, Nichole L King

  • 1Institute for Systems Biology, Seattle, WA, USA. fdesiere@yahoo.com

Nucleic Acids Research
|December 31, 2005
PubMed
Summary
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PeptideAtlas archives proteomic data, integrating it with genomic information. This platform uses tandem mass spectrometry (MS/MS) and statistical validation for reliable peptide and protein identification across diverse experiments.

Area of Science:

  • Proteomics
  • Genomics
  • Bioinformatics

Background:

  • The human genome project and high-throughput proteomic technologies necessitate automated data archiving.
  • Integrating proteomic and genomic data is crucial for biological research.
  • Existing data repositories lack standardized analysis for cross-experiment comparison.

Purpose of the Study:

  • To present PeptideAtlas, a repository for archiving and exchanging proteomic data.
  • To enable accurate integration of proteomic data with genomic data.
  • To establish a uniform process for peptide identification and validation.

Main Methods:

  • Peptide identification using tandem mass spectrometry (MS/MS).
  • Statistical validation of peptide and protein identifications.

Related Experiment Videos

  • Mapping identified peptide sequences to eukaryotic genomes.

    • Main Results:

    • PeptideAtlas provides a standardized approach for proteomic data analysis.
    • Uniform statistical validation ensures high-quality, consistent identifications.
    • The repository offers raw proteomic data in multiple formats for Human, Drosophila, and Yeast.

    Conclusions:

    • PeptideAtlas facilitates data exchange and integration between proteomic and genomic studies.
    • The platform ensures reliable and comparable proteomic data through a uniform analytic process.
    • This resource supports diverse research by providing accessible, validated proteomic datasets.