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Related Experiment Videos

MitoP2: the mitochondrial proteome database--now including mouse data.

H Prokisch1, C Andreoli, U Ahting

  • 1Institute of Human Genetics, Technical University of Munich, Munich, Germany. prokisch@gsf.de

Nucleic Acids Research
|December 31, 2005
PubMed
Summary
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The MitoP2 database provides integrated information on mitochondrial proteins, their functions, and associated diseases across yeast, human, and mouse. This resource aids in understanding mitochondrial evolution, predicting new proteins, and researching mitochondrial disease genes.

Area of Science:

  • Mitochondrial biology
  • Bioinformatics
  • Systems biology

Background:

  • Mitochondria are crucial organelles involved in cellular respiration and various diseases.
  • Understanding mitochondrial protein functions and their roles in disease is essential for biological research.
  • Existing databases may lack comprehensive integration of mitochondrial protein data, functions, and disease associations.

Purpose of the Study:

  • To develop and present the MitoP2 database, a centralized resource for mitochondrial protein information.
  • To facilitate the study of evolutionarily conserved mitochondrial functions and pathways.
  • To enable the identification of genes underlying mitochondrial diseases and support systems biology approaches.

Main Methods:

  • Manual annotation of reference proteins localized to or functionally associated with mitochondria in yeast, human, and mouse.

Related Experiment Videos

  • Integration of data from systematic genome-wide studies, including proteomics and deletion phenotype screening.
  • Development of methods for identifying orthologous proteins across species.
  • Implementation of data integration for predicting novel mitochondrial proteins with evidence scores.
  • Systematic search functionalities for disease-gene association studies.

    • Main Results:

    • The MitoP2 database is established, featuring manually curated mitochondrial proteins from yeast, human, and mouse.
    • The database enables identification of orthologous proteins, facilitating evolutionary studies.
    • It integrates diverse datasets, including proteomics and phenotype screening data.
    • MitoP2 supports the prediction of novel mitochondrial proteins and the search for disease-related genes.
    • Data is linked to PubMed and other databases, with downloadable files.

    Conclusions:

    • MitoP2 serves as a valuable, integrated resource for mitochondrial research.
    • The database empowers researchers to explore mitochondrial protein functions, evolutionary conservation, and disease associations.
    • It facilitates systems biology approaches to understand mitochondrial dysfunctions and their link to diseases.