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Published on: May 31, 2024
Biological studies of photoinducible phenol quaternary ammonium derivatives
Yang Song1, Ping Wang, Juanjuan Wu
1College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China.
Abstract:
Three water-soluble DNA cross-linking phenol quaternary ammonium derivatives 3, 4, and 5 could inhibit the transcription in vitro by photoactivation. DNA interstrand cross-linking action might be the key factor to inhibit transcription by these compounds. Further tumor cell apoptosis was observed by flow cytometry it indicated that cross-linking agent 5 could significantly induce the late apoptosis of tumor cells.
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