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Ocular changes after photodynamic therapy.

Radouil Tzekov1, Ton Lin, Kai-Ming Zhang

  • 1Department of Biological Sciences, Allergan Inc., Irvine, California 92612, USA. tzekov_radouil@allergan.com

Investigative Ophthalmology & Visual Science
|December 31, 2005
PubMed
Summary
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A single photodynamic therapy (PDT) session caused lasting morphologic and functional changes in the primate retina, affecting vision for up to nine months. Further research may explore mitigating these adverse effects.

Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Photodynamic Therapy

Background:

  • Photodynamic therapy (PDT) is a treatment modality used in ophthalmology.
  • Understanding the long-term effects of PDT on the primate visual system is crucial for clinical application.

Purpose of the Study:

  • To investigate the morphologic and functional changes in the primate retina following a single photodynamic therapy session.

Main Methods:

  • Two cynomolgus monkeys underwent PDT with verteporfin.
  • A comprehensive suite of imaging techniques including fundus photography, FA, ICG, OCT, and mfERG was employed.
  • Retinal histopathology was assessed at nine months post-treatment.

Main Results:

  • PDT induced persistent morphologic changes such as retinal whitening, RPE proliferation, and vascular closure.

Related Experiment Videos

  • Functional deficits in multifocal electroretinography (mfERG) were observed, with partial recovery over nine months.
  • Both treated and untreated retinal areas exhibited mfERG abnormalities, indicating potential spread or indirect effects.

    • Conclusions:

    • A single PDT session under standard clinical conditions causes dynamic, long-lasting retinal alterations in primates.
    • These findings highlight the importance of monitoring visual function post-PDT.
    • The study discusses the implications of these changes and potential interventions for adverse effects.