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Published on: January 27, 2023
Hypertension in young children and neonates
John Edward Jones1, Pedro A Jose
1Department of Pediatrics and Physiology and Biophysics, Georgetown University Medical Center, F2004 PHC, 4000 Reservoir Road NW, Washington, DC 20057, USA.
Insights
Early detection of hypertension precursors in children is crucial. Identifying at-risk individuals early can prevent severe health issues like heart disease and stroke later in life.
Area of Science:
- Cardiovascular Health
- Pediatric Medicine
- Genetics
Background:
- Hypertension is often viewed as a disease of older adults.
- However, its origins can be traced to early childhood, long before adult diagnosis.
- Essential hypertension involves a complex interplay of genetic and environmental factors.
Purpose of the Study:
- To emphasize the critical importance of early hypertension risk identification in children.
- To highlight the need for proactive measures before clinical manifestations appear.
Main Methods:
- Review of existing literature on hypertension development.
- Analysis of genetic and environmental factors influencing blood pressure.
- Identification of key risk indicators in pediatric populations.
Main Results:
- Precursors to hypertension are present in young children.
- Numerous genes affecting blood pressure are known, but specific links to essential hypertension remain elusive.
- Early identification of at-risk individuals is vital.
Conclusions:
- Hypertension risk assessment should begin in childhood.
- Early intervention strategies are essential for preventing long-term cardiovascular and renal complications.
- Further research is needed to pinpoint specific genetic components of essential hypertension.
Abstract:
Hypertension is most often considered a disease of old age, but the precursors are often present in young children long before the clinically accepted definitions of hypertension in the adult are manifested. Essential hypertension is by far the most common form of the disease, comprising a complex interaction of genetic and environmental factors. Many individual genes that play a role in the maintenance of blood pressure have been identified; however, none has been shown specifically to be a component of essential hypertension. Hypertension is among the leading risk factors for coronary heart disease, stroke, and end-stage renal disease, making it critically important to identify individuals at risk early in life prior to manifestation of clinical signs and symptoms.
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