Related Experiment Video
Updated: Aug 13, 2026

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression
Published on: July 30, 2015
A network model for the control of the differentiation process in Th cells
1Serono Pharmaceutical Research Institute, 14, Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland. luis.mendoza@serono.com
Abstract:
T helper cells differentiate from a precursor type, Th0, to either the Th1 or Th2 phenotypes. While a number of molecules are known to participate in this process, it is not completely understood how they regulate each other to ensure differentiation. This article presents the core regulatory network controlling the differentiation of Th cells, reconstructed from published molecular data. This network encompasses 17 nodes, namely IFN-gamma, IL-4, IL-12, IL-18, IFN-beta, IFN-gammaR, IL-4R, IL-12R, IL-18R, IFN-betaR, STAT-1, STAT-6, STAT-4, IRAK, SOCS-1, GATA-3, and T-bet, as well as their cross-regulatory interactions. The reconstructed network was modeled as a discrete dynamical system, and analyzed in terms of its constituent feedback loops. The stable steady states of the Th network model are consistent with the stable molecular patterns of activation observed in wild type and mutant Th0, Th1 and Th2 cells.
Related Concept Videos
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Differentiation of Common Myeloid Progenitor Cells
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cellular Differentiation
A zygote is a...
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Forced Transdifferentiation
Artificial transdifferentiation occurs...

