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Electrohydrodynamics in hierarchically structured monolithic and particulate fixed beds.

Ivo Nischang¹, Guofang Chen, Ulrich Tallarek

¹Institut für Verfahrenstechnik, Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany.

Journal of Chromatography. A

|January 3, 2006

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Concentration polarization (CP) in capillary electrochromatography (CEC) significantly impacts electroosmotic flow (EOF) and analyte dispersion. Understanding CP

Area of Science:

Analytical Chemistry
Separation Science
Electrochemistry

Background:

Capillary electrochromatography (CEC) relies on electroosmotic flow (EOF) for analyte transport and separation.
Silica-based porous media in CEC exhibit hierarchical structures with distinct mesoporous and macroporous domains.
The ion-permselectivity of mesoporous domains influences electrolyte concentration and electrical double layer (EDL) phenomena.

Purpose of the Study:

To investigate the fundamental dependence of EOF velocity and hydrodynamic dispersion in CEC on applied field and mobile phase ionic strengths.
To elucidate the role of concentration polarization (CP) in silica-based particulate and monolithic beds.
To understand how CP affects EOF dynamics, dispersion, and analyte retention.

Main Methods:

Related Experiment Videos

Experimental investigation of EOF velocity and hydrodynamic dispersion.
Employing silica-based particulate and monolithic fixed beds.
Varying applied electrical field and mobile phase ionic strengths.

Main Results:

Concentration polarization (CP) arises from electrical field-induced coupled mass and charge transport across charge-selective interfaces.
CP creates depleted and enriched electrolyte zones, influencing EOF and dispersion.
Induced-charge EOF in macroporous domains shows nonlinear dependence on field strength and enhances lateral dispersion.
Pore space morphology critically affects CP intensity and induced-charge EOF.

Conclusions:

CP is a key phenomenon in CEC, significantly impacting EOF, hydrodynamic dispersion, and analyte retention.
The interplay between applied field, ionic strength, and porous structure governs CP and its consequences.
Understanding CP is crucial for optimizing CEC performance and method development.